Fig. 6
From: Neurodegenerative disorders, metabolic icebergs, and mitohormesis

ALS as a metabolic iceberg. ALS amyotrophic lateral sclerosis, TDP-43 transactive response DNA binding protein 43, ATP adenosine triphosphate, TCA tricarboxylic acid, ETC electron transport chain, mtDNA mitochondrial DNA, C9orf72 chromosome 9 open reading frame 72, SOD1 superoxide dismutase 1, FUS fused in sarcoma