Fig. 1

Correlations of plasma mid-p-tau or N-p-tau level with tau or amyloid PET in the subjects with AD continuum. a The correlation between plasma mid-p-tau181 level and ¹⁸F-florzorotau tau PET is depicted through its topographical representation (P < 0.05, FWE-corrected). b, c Scatter plots of the correlation between plasma mid-p-tau181 level and tau PET tracer accumulation in each ROI. Pearson's correlation analysis was employed to calculate the r and P values. Statistical significance was established at P < 0.0125, corrected for multiple comparisons using the Bonferroni method. Regression analysis, indicated by a straight or curved line, depicts the preferred model, with its goodness of fit quantified using the R² value. d Topographical representation of the correlation between plasma N-p-tau181 level and tau PET (P < 0.05, uncorrected). e, f Scatter plots of the correlation between plasma N-p-tau181 level and tau PET tracer accumulation in each ROI. The procedure for the correlation analysis was the same as that in b and c. g Topographical representation of the correlations of each plasma p-tau181 assay with amyloid- (left column) and tau- (right column) PET in the CN and AD continuum cohort (P < 0.05, FWE-corrected). h Bar graphs illustrating beta coefficient values of amyloid and tau PET in multiple liner regression analysis with each p-tau assay. *P < 0.05, **P < 0.005, ****P < 0.0005. P-values were corrected for multiple comparisons using Bonferonni correction with the number of explanatory variables