Fig. 2
Cholinergic signaling did not differ from non-transgenic in late AD. a Representative opto-ACh responses from non-transgenic (nTg) control (black) and TgCRND8 AD (grey) neurons at late stage of disease measured in voltage clamp (Vm = − 75 mV). b, c Graphs show no difference in rising speed (b) and peak amplitude (c) of opto-ACh currents in TgCRND8 late-AD responses compared to age-matched controls. d Representative opto-ACh responses from WT control (black) and TgCRND8 AD (grey) neurons at late stage of disease measured in current clamp. e, f Graphs show no difference in firing rise (e) and peak firing frequency (f) of opto-ACh firing responses in TgCRND8 late-AD responses compared to age-matched controls. Mice aged 7–12 months (nTg: 9.3 ± 0.5 months, n = 10 animals, 3–4 brain slices per animal, TgCRND8: 10.1 ± 0.6 months, n = 10 animals, 3–4 brain slices per animal)