Skip to main content
Fig. 3 | Translational Neurodegeneration

Fig. 3

From: N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson’s disease

Fig. 3

Representative confocal images showing different epitope-specific aggregate structures found in PD and MSA. a Perinuclear, glial, and lysosomal α-Syn aggregates with exclusive N-terminus immunoreactivity in the human brain with PD. b Different epitope-specific aggregate structures found in MSA. (1) Punctate aggregates exhibiting exclusive N-terminus immunoreactivity were commonly observed within neuronal cytoplasm. (2) Neuronal inclusions with exclusive N-terminus immunoreactivity were frequently observed in the inferior olivary nucleus. (3, 4) Filamentous neuronal inclusions with exclusive portions of N-terminus immunoreactivity and exclusive portions of C-terminus immunoreactivity were common. (5) Oligodendroglial inclusion exhibiting variable N-terminus, pS129, and C-terminus immunoreactivity. (1–4, 6) pS129 α-Syn immunolabelling was often very weak or, in some instances, completely absent. Yellow and magenta arrowheads label instances of unique N-terminus and C-terminus immunolabelling, respectively. Scale bars, 5 μm

Back to article page

Translational Neurodegeneration

ISSN: 2047-9158

Contact us