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Fig. 6 | Translational Neurodegeneration

Fig. 6

From: N-terminus α-synuclein detection reveals new and more diverse aggregate morphologies in multiple system atrophy and Parkinson’s disease

Fig. 6

Illustration summarising the prevailing α-Syn aggregate structures that are present in PD and MSA. In the human brain with PD, novel perinuclear, microglial, astrocytic, and lysosomal α-Syn aggregate structures that exhibit epitope-specific N-terminus (residues 34–57) immunoreactivity were observed. In the human brain with MSA, microglial and astrocytic inclusions were not observed. Punctate neuronal inclusions with exclusive N-terminus immunoreactivity were often observed; however, these were considerably less frequent than in PD (not included in the illustration). Structurally discrete, whisp-like α-Syn filaments with either exclusive N-terminus or exclusive C-terminus immunoreactivity were frequently observed, which appeared to be interlaced and juxtaposed with one another. Finally, in the MSA ION, several neuronal inclusions with exclusive N-terminus immunoreactivity were observed (not included in the illustration)

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Translational Neurodegeneration

ISSN: 2047-9158

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