Skip to main content
Fig. 2 | Translational Neurodegeneration

Fig. 2

From: Blood–brain barrier disruption: a pervasive driver and mechanistic link between traumatic brain injury and Alzheimer's disease

Fig. 2

Regulation of BBB permeability by APOE4. APOE4 secreted by astrocytes has a low binding affinity for the low-density lipoprotein receptor-related protein 1 (LRP1) on pericytes. This weak binding activates the proinflammatory CypA/MMP-9 pathway, which results in release of MMP-9 into the extracellular space. Here, MMP-9 enzymatically degrades the basement membrane (BM) and junction proteins, leading to BBB breakdown. Created with BioRender.com

Back to article page

Translational Neurodegeneration

ISSN: 2047-9158

Contact us